Influence of time-dependent sampling on fish plasma levels of select pharmaceuticals and per- and polyfluoroalkyl substances (PFASs)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F22%3A43904605" target="_blank" >RIV/60076658:12520/22:43904605 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.envpol.2022.120338" target="_blank" >https://doi.org/10.1016/j.envpol.2022.120338</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2022.120338" target="_blank" >10.1016/j.envpol.2022.120338</a>

Result language

angličtina

Original language name

Influence of time-dependent sampling on fish plasma levels of select pharmaceuticals and per- and polyfluoroalkyl substances (PFASs)

Original language description

Determining pharmaceutical levels in fish plasma represents an increasingly valuable approach for environ-mental assessments of pharmaceuticals. These fish plasma observations are compared to human therapeutic plasma doses because of the high evolutionary conservation of many drug targets among vertebrates. In the present study, we initially identified highly variable information regarding plasma sampling practices in the literature and then tested the hypothesis that fish plasma levels of selected pharmaceuticals and per-and pol-yfluoroalkyl substances (PFASs) would not change with time to process samples from the field. After common carp were placed in a wastewater-fed pond for one month, we immediately sampled fish plasma nonlethally in the field or after transferring fish to clean water and held them under these conditions for either 3 or 20 h. We then quantitated pharmaceuticals in water, and pharmaceuticals and PFASs in plasma by LC-MSMS. Whereas plasma levels of most pharmaceuticals decreased even after 3 h that fish spent in clean water, plasma concen-trations of the PFASs examined here remained stable over 20 h. Collectively, our examination of these time -dependent sampling approaches and associated findings highlight the importance of appropriate and consis-tent sampling for bioaccumulation studies, biomonitoring activities, and aquaculture product safety evaluations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Pollution

ISSN

0269-7491

e-ISSN

1873-6424

Volume of the periodical

315

Issue of the periodical within the volume

neuvedeno

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

nestrankovano

UT code for WoS article

000870025800001

EID of the result in the Scopus database

2-s2.0-85139736767