Evolution of the nitric oxide synthase family in vertebrates and novel insights in gill development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F22%3A43905329" target="_blank" >RIV/60076658:12520/22:43905329 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10448335
Result on the web
<a href="https://doi.org/10.1098/rspb.2022.0667" target="_blank" >https://doi.org/10.1098/rspb.2022.0667</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rspb.2022.0667" target="_blank" >10.1098/rspb.2022.0667</a>
Alternative languages
Result language
angličtina
Original language name
Evolution of the nitric oxide synthase family in vertebrates and novel insights in gill development
Original language description
Nitric oxide (NO) is an ancestral key signalling molecule essential for life and has enormous versatility in biological systems, including cardiovascular homeostasis, neurotransmission and immunity. Although our knowledge of NO synthases (Nos), the enzymes that synthesize NO in vivo, is substantial, the origin of a large and diversified repertoire of nos gene orthologues in fishes with respect to tetrapods remains a puzzle. The recent identification of nos3 in the ray-finned fish spotted gar, which was considered lost in this lineage, changed this perspective. This finding prompted us to explore nos gene evolution, surveying vertebrate species representing key evolutionary nodes. This study provides noteworthy findings: first, nos2 experienced several lineage-specific gene duplications and losses. Second, nos3 was found to be lost independently in two different teleost lineages, Elopomorpha and Clupeocephala. Third, the expression of at least one nos paralogue in the gills of developing shark, bichir, sturgeon, and gar, but not in lamprey, suggests that nos expression in this organ may have arisen in the last common ancestor of gnathostomes. These results provide a framework for continuing research on nos genes' roles, highlighting subfunctionalization and reciprocal loss of function that occurred in different lineages during vertebrate genome duplications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the Royal Society of London Series B - Biological Sciences
ISSN
0962-8452
e-ISSN
1471-2954
Volume of the periodical
289
Issue of the periodical within the volume
1980
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
nestrankovano
UT code for WoS article
000838576600010
EID of the result in the Scopus database
2-s2.0-85135732009