Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F23%3A43906590" target="_blank" >RIV/60076658:12520/23:43906590 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1080/10495398.2021.2016434" target="_blank" >https://doi.org/10.1080/10495398.2021.2016434</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10495398.2021.2016434" target="_blank" >10.1080/10495398.2021.2016434</a>
Alternative languages
Result language
angličtina
Original language name
Determination of the relationship between class IV sirtuin genes and growth traits in Chinese black Tibetan sheep
Original language description
Class IV sirtuin (SIRT6 and SIRT7) played essential roles in biometabolism processes via deacetylating specific transcription factors. The present study was conducted to search for mutations in SIRT6/7 and determine their associations with growth traits in black Tibetan sheep. Via DNA sequencing methods, three single-nucleotide polymorphisms (SNPs) were identified in 427 ewes, including a mutation (g.3724C > T) in the intron 1 of SIRT6 and two mutations (g.3668G > T and g.4223C > G) in SIRT7 intron 6 and 8, respectively. Based on the chi(2) test, both g.3724C > T and g.4223C > G loci fitted with Hardy-Weinberg equilibrium (p > 0.05). Compared with animals with genotype TT, the CC genotype at g.3724C > T locus (SIRT6) exhibited the highest mean for body weight (p < 0.05) and heart girth (p < 0.05). At g.3668G > T locus (SIRT7), individuals carrying the GG genotype tended to have heavier body weight than those of TT genotype (p < 0.05). With the exception of body weight, body measurement traits not affected by combinative genotype (p > 0.05). Our results could be used as genetic markers for marker-assisted selection and maybe guide sheep breeding in economic traits.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40201 - Animal and dairy science; (Animal biotechnology to be 4.4)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Animal Biotechnology
ISSN
1049-5398
e-ISSN
1532-2378
Volume of the periodical
34
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1232-1238
UT code for WoS article
000731246100001
EID of the result in the Scopus database
2-s2.0-85121692366