Neural crest origin of sympathetic neurons at the dawn of vertebrates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F24%3A43908127" target="_blank" >RIV/60076658:12520/24:43908127 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41586-024-07297-0" target="_blank" >https://doi.org/10.1038/s41586-024-07297-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41586-024-07297-0" target="_blank" >10.1038/s41586-024-07297-0</a>
Alternative languages
Result language
angličtina
Original language name
Neural crest origin of sympathetic neurons at the dawn of vertebrates
Original language description
The neural crest is an embryonic stem cell population unique to vertebrates1 whose expansion and diversification are thought to have promoted vertebrate evolution by enabling emergence of new cell types and structures such as jaws and peripheral ganglia2. Although jawless vertebrates have sensory ganglia, convention has it that trunk sympathetic chain ganglia arose only in jawed vertebrates3–8. Here, by contrast, we report the presence of trunk sympathetic neurons in the sea lamprey, Petromyzon marinus, an extant jawless vertebrate. These neurons arise from sympathoblasts near the dorsal aorta that undergo noradrenergic specification through a transcriptional program homologous to that described in gnathostomes. Lamprey sympathoblasts populate the extracardiac space and extend along the length of the trunk in bilateral streams, expressing the catecholamine biosynthetic pathway enzymes tyrosine hydroxylase and dopamine β-hydroxylase. CM-DiI lineage tracing analysis further confirmed that these cells derive from the trunk neural crest. RNA sequencing of isolated ammocoete trunk sympathoblasts revealed gene profiles characteristic of sympathetic neuron function. Our findings challenge the prevailing dogma that posits that sympathetic ganglia are a gnathostome innovation, instead suggesting that a late-developing rudimentary sympathetic nervous system may have been characteristic of the earliest vertebrates. © The Author(s), under exclusive licence to Springer Nature Limited 2024.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
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Volume of the periodical
629
Issue of the periodical within the volume
8010
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
121-126
UT code for WoS article
001207592700009
EID of the result in the Scopus database
2-s2.0-85190640917