The killifish germline regulates longevity and somatic repair in a sex-specific manner

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F24%3A43908155" target="_blank" >RIV/60076658:12520/24:43908155 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1038/s43587-024-00632-0" target="_blank" >https://doi.org/10.1038/s43587-024-00632-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s43587-024-00632-0" target="_blank" >10.1038/s43587-024-00632-0</a>

Result language

angličtina

Original language name

The killifish germline regulates longevity and somatic repair in a sex-specific manner

Original language description

Classical evolutionary theories propose tradeoffs among reproduction, damage repair and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. In this study, we used the turquoise killifish (Nothobranchius furzeri) to genetically arrest germline development at discrete stages and examine how different modes of infertility impact life history. We first constructed a comprehensive single-cell gonadal atlas, providing cell-type-specific markers for downstream phenotypic analysis. We show here that germline depletion-but not arresting germline differentiation-enhances damage repair in female killifish. Conversely, germline-depleted males instead showed an extension in lifespan and rejuvenated metabolic functions. Through further transcriptomic analysis, we highlight enrichment of pro-longevity pathways and genes in germline-depleted male killifish and demonstrate functional conservation of how these factors may regulate longevity in germline-depleted Caenorhabditis elegans. Our results, therefore, demonstrate that different germline manipulation paradigms can yield pronounced sexually dimorphic phenotypes, implying alternative responses to classical evolutionary tradeoffs. Moses, Atlan et al. profile the killifish (Nothobranchius furzeri) gonad using single-cell sequencing and reveal that genetic germline depletion induces sexually dimorphic phenotypes, enhancing lifespan in male fish and somatic repair in females.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Aging

ISSN

2662-8465

e-ISSN

2662-8465

Volume of the periodical

4

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

38

Pages from-to

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UT code for WoS article

001223453900001

EID of the result in the Scopus database

2-s2.0-85192893752