Differential effects of antidepressant sertraline in glochidia-fish interactions involving drug transfer from parasite to host

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F24%3A43908164" target="_blank" >RIV/60076658:12520/24:43908164 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/24:98340 RIV/60460709:41310/24:98340

Result on the web

<a href="https://doi.org/10.1016/j.aquatox.2024.107012" target="_blank" >https://doi.org/10.1016/j.aquatox.2024.107012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2024.107012" target="_blank" >10.1016/j.aquatox.2024.107012</a>

Result language

angličtina

Original language name

Differential effects of antidepressant sertraline in glochidia-fish interactions involving drug transfer from parasite to host

Original language description

This study examined the impact of sertraline, an antidepressant common in treated wastewater, on the hostparasite dynamics between parasitic freshwater mussel (Unio tumidus, Unionidae) larvae (glochidia) and their host fish (Squalius cephalus, Cyprinidae). Employing a full-factorial design, both fish and glochidia were subjected to sertraline at the combinations of 0 mu g L- 1 (control), 0.2 mu g L-1 (environmentally relevant concentration), and 4 mu g L-1 (elevated concentration, short-term exposure of the parasite). The results showed that long-term host exposure (involving intensive sertraline accumulation in the fish brain) marginally increased subsequent glochidia attachment success by 2 %, while parasite exposure at the same environmentally relevant concentrations had no detectable effect. There was also no effect of exposure of glochidia to 0.2 mu g L-1 of sertraline on their viability and encapsulation success during the initial parasitic stage. However, a significant alteration in attachment behavior, marked by a 3.3 % increase in attachment success and changes in the glochidia spatial distribution on the host body, was noted after 24 h of glochidia exposure to 4 mu g L-1 of sertraline. Importantly, this study provides the first evidence of sertraline transfer from exposed glochidia to nonexposed host fish, as indicated by elevated levels of sertraline (12.8 ng g- 1) in the brain tissue of nonexposed hosts. These findings highlight the subtle yet significant effects of pharmaceutical pollutants on freshwater ecosystems but also underscore the importance of understanding the unexpected dynamics of such contamination to predict and address future ecological changes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Aquatic Toxicology

ISSN

0166-445X

e-ISSN

1879-1514

Volume of the periodical

273

Issue of the periodical within the volume

neuvedeno

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

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UT code for WoS article

001264365300001

EID of the result in the Scopus database

2-s2.0-85197071856