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Effect of exposure to bisphenol A and 17ß-estradiol on the sex differentiation in zebrafish (Danio rerio)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12610%2F05%3A00006265" target="_blank" >RIV/60076658:12610/05:00006265 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of exposure to bisphenol A and 17ß-estradiol on the sex differentiation in zebrafish (Danio rerio)

  • Original language description

    The effects of bisphenol A and 17ß-estradiol on sex differentiation were investigated in the zebrafish, Danio rerio. The 20-day-old fry with undifferentiated gonads were fed with food containing bisphenol A at the dose of 500, 1000, 2000 mg.kg-1 and 17ß-estradiol at the dose of 20 mg.kg-1 diet for 45 days. Sex ratio and gonadal development after the chemical treatment were determined by histological examination of gonads. In the control group, the sex ratio of fry was 1:1 (female:male), i.e. 50% of females and 50% of males appeared. The sex of fry fed with 17ß-estradiol at the dose of 20 mg.kg-1 diet was all females. Feminization of the fry was induced by exogenic 17ß-estradiol. The sex of fry fed with bisphenol A at the dose of 500, 1000, 2000 mg.kg-1diet was 1.4:1 (p = 0.31), 3.8:1 (p = 0.01) and 11.5:1 (p < 0.01). Bisphenol A induced feminization of the fry at the two highest doses tested.

  • Czech name

    Vliv bisfenolu A a 17ß-estradiolu na diferenciaci pohlaví u dánia pruhovaného (Danio rerio)

  • Czech description

    Vliv bisfenolu A a 17ß-estradiolu na diferenciaci pohlaví byl zhodnocen u dánia pruhovaného, Danio rerio. 20-ti denní plůdek s nediferencovanými gonádami byl krmen dietou obsahující bisfenol A a 17ß-estradiol v koncentraci 500, 1000, 2000 mg.kg-1 a 20 mg.kg-1 po dobu 45 dnů. Poměr pohlaví a vývoj gonád byl určen na základě histologického vyšetření. V kontrolní skupině byl poměr pohlaví 1:1, tzn. 50 % samic a 50 % samců. Pohlaví u plůdku krmeného krmivem obsahujícím 17ß-estradiol v dávce 20 mg.kg-1 bylo100 % samic. Feminizace plůdku byla způsobena exogenním 17ß-estradiolem. Poměr pohlaví u plůdku krmeného krmivem obsahujícím bisfenol A v dávce 500, 1000, 2000 mg.kg-1 bylo 1.4:1 (p = 0.31), 3.8:1 (p = 0.01) a 11.5:1 (p < 0.01). Bisfenol A způsobil feminizaci plůdku ve dvou nejvyšších testovaných koncentracích.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Veterinaria Brno

  • ISSN

    0001-7213

  • e-ISSN

  • Volume of the periodical

    74

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    287-291

  • UT code for WoS article

  • EID of the result in the Scopus database