Computational Modelling of Catalytic Properties and Modified Substrates of Fungal beta-N-Acetylhexosaminidases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12640%2F11%3A43882314" target="_blank" >RIV/60076658:12640/11:43882314 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Computational Modelling of Catalytic Properties and Modified Substrates of Fungal beta-N-Acetylhexosaminidases
Original language description
Besides their implication in human physiology and disease, beta-N-acetylhexosaminidases (EC 3.2.1.52, CAZy GH 20) have recently gained a lot of attention thanks to their great potential in the enzymatic synthesis of carbohydrates and glycomimetics. Extracellular beta-N-acetylhexosaminidases from filamentous fungi proved to be a powerful synthetic tool for the preparation of both natural and modified glycosides under mild conditions with good yields. A homology model of beta-N-acetylhexosaminidase from the filamentous fungus Aspergillus oryzae has recently been reported, and its quality was corroborated by vibrational spectroscopy and biochemical studies. Computational modelling and analysis helped to identify active site amino acids and other basic structural features of this enzyme important in the catalytic process; moreover, the surface interactions of the subunits of the glycosylated enzyme were identified. The model of beta-N-acetylhexosaminidase from Aspergillus oryzae prepared t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini-Reviews in Organic Chemistry
ISSN
1570-193X
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
3
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
11
Pages from-to
270-280
UT code for WoS article
000294408500008
EID of the result in the Scopus database
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