Knockdown of proteins involved in iron metabolism limits tick reproduction and development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00327046" target="_blank" >RIV/60077344:_____/09:00327046 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/09:00010486
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Knockdown of proteins involved in iron metabolism limits tick reproduction and development
Original language description
We have characterized a new secreted ferritin (Fer2) and an iron regulatory protein (IRP1) from the hard tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (Fer1). Using RNA interference,we have proved that Fer2 plays a role as a transporter of non-heme iron from the tick gut to the periheral tissues. Knockdown of Fer2 dramatically impairs the ability of ticks to feed, thus making Fer2 a promising candidate for development of an efficient anti-tick vaccine.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000262831600016
EID of the result in the Scopus database
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