Antitumor activity od apoptotic nuclease TBN1 from L. esculentum

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00346342" target="_blank" >RIV/60077344:_____/10:00346342 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/10:00346342
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antitumor activity od apoptotic nuclease TBN1 from L. esculentum
Original language description
Nuclease from tomato (TBN1) wad produced by in planta biotechnology, purified and tested for its antitumor properties. The nuclease was cytostatic after its intratumoral administration to nude mice bearing human melanoma or prostate carcinoma, and also after tumor targeting by its intravenous administration as conjugate with PEG. Inhibitory effects of TBN1 on tumor growth were comparable to effects of bovine seminal RNase (BS-RNase), but the inhibition was reached at about ten times lower protein concentration. Intravenous administration of TBN1-PEG caused significant inhibition of tumor proliferation without obvious degenerative changes, while direct administration of TBN1 into melanoma tumors led to rapid tumor tissue degeneration. Simultaneously, TBN1 exhibited a lower degree of embryotoxicity compared to BS-RNase and other nucleases.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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