Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00359447" target="_blank" >RIV/60077344:_____/11:00359447 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/11:43882598 RIV/60076658:12220/11:43882598 RIV/60076658:12510/11:43882598
Result on the web
<a href="http://dx.doi.org/10.1111/j.1365-3024.2010.01271.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-3024.2010.01271.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1365-3024.2010.01271.x" target="_blank" >10.1111/j.1365-3024.2010.01271.x</a>
Alternative languages
Result language
angličtina
Original language name
Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections
Original language description
The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/KJB500960701" target="_blank" >KJB500960701: Immune response of mice to infection with different gastric cryptosporidia from mammals</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasite immunology
ISSN
0141-9838
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
210-216
UT code for WoS article
000288249400002
EID of the result in the Scopus database
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