Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364747" target="_blank" >RIV/60077344:_____/11:00364747 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis
Original language description
Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.
Czech name
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Czech description
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms
ISBN
978-1-4419-8413-5
Number of pages of the result
19
Pages from-to
136-154
Number of pages of the book
222
Publisher name
SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197
Place of publication
BERLIN
UT code for WoS chapter
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