Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364839" target="_blank" >RIV/60077344:_____/11:00364839 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1074/jbc.M111.247924" target="_blank" >http://dx.doi.org/10.1074/jbc.M111.247924</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/jbc.M111.247924" target="_blank" >10.1074/jbc.M111.247924</a>
Alternative languages
Result language
angličtina
Original language name
Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity
Original language description
The function of a mosquito anticoagulant serpin named as Alboserpin is presented. The recombinant protein binds to phospholipids and it inhibits the activity of human coagulation factor Xa. Binding is highly specific and is not detectable for FX, catalytic site-blocked FXa, thrombin and 12 other enzymes. Alboserpin displays high-affinity binding to heparin, but no change in FXa inhibition was observed in the presence of the cofactor, implying that bridging mechanisms did not take place. Alboserpin displays a potent pharmacological activity since it prevents thrombus formation provoked by ferric chloride injury of the carotid artery and it increases bleeding in a dose-dependent manner.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
286
Issue of the periodical within the volume
32
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
27998-28010
UT code for WoS article
000293557800018
EID of the result in the Scopus database
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