QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00367836" target="_blank" >RIV/60077344:_____/11:00367836 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12410/11:43882657

Result on the web

<a href="http://dx.doi.org/10.1016/j.cub.2011.03.049" target="_blank" >http://dx.doi.org/10.1016/j.cub.2011.03.049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cub.2011.03.049" target="_blank" >10.1016/j.cub.2011.03.049</a>

Result language

angličtina

Original language name

QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock

Original language description

We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL),quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

<a href="/en/project/LC07032" target="_blank" >LC07032: Center for Functional Genetics</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Biology

ISSN

0960-9822

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

719-729

UT code for WoS article

000290553800021

EID of the result in the Scopus database

—