A myth about the ?potent cardiostimulating? action of insect neuropeptides has been unfounded

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00376155" target="_blank" >RIV/60077344:_____/11:00376155 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A myth about the ?potent cardiostimulating? action of insect neuropeptides has been unfounded
Original language description
Chemists and biochemists isolating or synthesizing insect neuropeptides used to create a myth about ?potent cardiostimulating properties of these peptides. The myth was motivated by a tendency to gain professional importance and scientific merit of theirwork. Crucial arguments in favour of the idea were obtained by simple, largely nonspecific, in vitro bioassays performed on isolated hearts of cockroaches in saline. These assays gave positive responses to a wide range of low molecular compounds as wellas to most peptides tested. Our attempts to solve this problem started by development of new touch-free electrocardiographic methods for monitoring the heartbeat of unrestrained insects. Extensive in vivo recordings revealed that the tentatively ?cardioactive neuropeptides had no cardiostimulating activity under physiological conditions. Intimate similarities appeared between regulation of insect and human hearts. Accordingly, a cardioactive peptide does not exist in human medicine as w
Czech name
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Czech description
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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