Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00375986" target="_blank" >RIV/60077344:_____/12:00375986 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/12:00375986 RIV/60076658:12310/12:43883524
Result on the web
<a href="http://www.pnas.org/content/109/10/3808.full.pdf+html" target="_blank" >http://www.pnas.org/content/109/10/3808.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1201089109" target="_blank" >10.1073/pnas.1201089109</a>
Alternative languages
Result language
angličtina
Original language name
Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability
Original language description
Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens, a plant parasite. We found thatit lacks most of the known hemoproteins and does not require heme for electron transport in the respiratory chain, protection against oxidative stress, or desaturation of fatty acids. Although heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorporated into the membranes of P. serpens grown in the absence of heme. In conclusion, P. serpens is a flagellate with unique metabolic adaptations that allow it to bypass all requirements for heme.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
3808-3813
UT code for WoS article
000301117700045
EID of the result in the Scopus database
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