Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00375991" target="_blank" >RIV/60077344:_____/12:00375991 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1161/ATVBAHA.111.240291" target="_blank" >http://dx.doi.org/10.1161/ATVBAHA.111.240291</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/ATVBAHA.111.240291" target="_blank" >10.1161/ATVBAHA.111.240291</a>
Alternative languages
Result language
angličtina
Original language name
Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria
Original language description
The therapeutic use of defibrotide (DF) in malaria is proposed. DF blocks the induction of endothelial tissue factor-mediated coagulation by parasitized red blood cells. At a concentration achievable in vivo, DF suppresses Toll-like receptors 4 and 2 agonist-driven proinflammatory cytokine production by dendritic cells (DCs). We demonstrate that DF directly decreases platelet aggregation and blocks the alternative complement pathway further proposing that DF may act through adenosine receptors. Accordingly, we observe that DF-exposed DCs produce prostaglandin E2 and have enhanced lipopolysaccharide-induced IL-10 secretion. DF blocks parasite invasion of red blood cells and rosetting and the agglutination of parasitized red blood cells. Finally, DF abolishes oocysts development in Anopheles gambiae; in a murine model of cerebral malaria, DF affected parasitemia, decreased IFN-? levels, and ameliorated clinical score (day 5) with a trend for increased survival.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Arteriosclerosis Thrombosis and Vascular Biology
ISSN
1079-5642
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
786-798
UT code for WoS article
000300639300035
EID of the result in the Scopus database
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