Tick saliva-mediated immunomodulation of the vertebrate host

Result code in IS VaVaI
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Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Tick saliva-mediated immunomodulation of the vertebrate host
Original language description
The feeding period of hard ticks often exceeds one week and makes tick infestation a considerable intervention to host physiology. A broad range of inflammatory and immune reactions take place locally at the feeding site as well as systemically within the host body. Active modulation of the host immune response by tick saliva is thus required for the tick to complete its blood meal. Upon attachment, the tick inoculates its saliva containing a repertoire of bioactive molecules that help ticks to attach to the host, to overcome host hemostasis, and to prevent host pain and itching and the concomitant scratching. Furthermore, the tick must deal with the host innate immunity during primary infestation and with innate and adaptive immunity in subsequent infestations. The immunomodulatory properties of tick saliva and the roles of individual salivary components at the tick-host interface are described in this chapter, dealing with virtually all levels of nonspecific and specific host immune
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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