Biosynthesis of Colabomycin E, a New Manumycin-Family Metabolite, Involves an Unusual Chain-Length Factor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00434468" target="_blank" >RIV/60077344:_____/14:00434468 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00434468 RIV/68378050:_____/14:00434468 RIV/00023001:_____/14:00059042
Result on the web
<a href="http://dx.doi.org/10.1002/cbic.201400068" target="_blank" >http://dx.doi.org/10.1002/cbic.201400068</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.201400068" target="_blank" >10.1002/cbic.201400068</a>
Alternative languages
Result language
angličtina
Original language name
Biosynthesis of Colabomycin E, a New Manumycin-Family Metabolite, Involves an Unusual Chain-Length Factor
Original language description
Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 and identified by genetic screening from a library of streptomycete strains. The structures of colabomycin E and accompanying congeners were resolved. The entire biosynthetic gene cluster was cloned and expressed in Streptomyces lividans. Bioinformatic analysis and mutagenic studies identified components of the biosynthetic pathway that are involved in the formation of both polyketide chains. Recombinant polyketide synthases (PKSs) assembled from the components of colabomycin E and asukamycin biosynthetic routes catalyzing the biosynthesis of "lower" carbon chains were constructed and expressed in S. aureus SOK1/5-04 Delta colC11-14 deletion mutant. Analysis of the metabolites produced by recombinant strains provided evidence that in both biosynthetic pathways the length of the lower carbon chain is controlled by an unusual chain-length factor supporting biosynthesis eit
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13012" target="_blank" >NT13012: The effect of manumycin-related compounds on innate immunity cells and their interactions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chembiochem
ISSN
1439-4227
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
1334-1345
UT code for WoS article
000337638400016
EID of the result in the Scopus database
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