Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00439555" target="_blank" >RIV/60077344:_____/14:00439555 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/14:43887340

Result on the web

<a href="http://dx.doi.org/10.1093/nar/gku657" target="_blank" >http://dx.doi.org/10.1093/nar/gku657</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gku657" target="_blank" >10.1093/nar/gku657</a>

Result language

angličtina

Original language name

Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses

Original language description

Arboviruses are transmitted by distantly related arthropod vectors such as mosquitoes (class In-secta) and ticks (class Arachnida). RNA interference (RNAi) is the major antiviral mechanism in arthropods against arboviruses. Unlike in mosquitoes, tick antiviral RNAi is not understood, although this information is important to compare arbovirus/host interactions in different classes of arbovirus vectos. Using an Ixodes scapularis-derived cell line, key Argonaute proteins involved in RNAi and the responseagainst tick-borne Langat virus (Flaviviridae) replication were identified and phylogenetic relationships characterized. Analysis of small RNAs in infected cells showed the production of virus-derived small interfering RNAs (viRNAs), which are key molecules of the antiviral RNAi response. Importantly, viRNAs were longer (22 nucleotides) than those from other arbovirus vectors and mapped at highest frequency to the termini of the viral genome, as opposed to mosquito-borne flaviviruses. Mo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GAP302%2F12%2F2490" target="_blank" >GAP302/12/2490: Tick-borne encephalitis virus-host interaction on the molecular, cellular and organismal level</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

14

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

9436-9446

UT code for WoS article

000343219200056

EID of the result in the Scopus database

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