Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00441941" target="_blank" >RIV/60077344:_____/15:00441941 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/15:43889001
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0022191015000037" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022191015000037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinsphys.2015.01.001" target="_blank" >10.1016/j.jinsphys.2015.01.001</a>

Result language
angličtina
Original language name
Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila
Original language description
The impact of mutations in four essential genes involved in dopamine (DA) synthesis and transport on longevity, motor behavior, and resistance to oxidative stress was monitored in Drosophila melanogaster. Median lifespans of ple2, PuZ22 and VMAT?14 mutants were significantly decreased compared to Catsup26 and wild type controls that did not significantly differ between each other. Catsup26 flies survived longer when exposed to HP or PQ compared to ple2, PuZ22 or VMAT?14 and controls. These flies also exhibited significantly higher negative geotaxis activity compared to ple2, PuZ22, VMAT?14 and controls. All mutant flies demonstrated rhythmic circadian locomotor activity in general, albeit Catsup26 and VMAT?14 flies had slightly weaker rhythms. Expression analysis of some key antioxidant genes revealed that GSTO1 expression was significantly up-regulated in all DA synthesis pathway mutants and especially in Catsup26 and VMAT?14 flies at both mRNA and protein levels. Taken together, we h
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/LH14047" target="_blank" >LH14047: Hormonal control of anti-stress reactions in insects</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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