Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila ? A role for dFoxO?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00444024" target="_blank" >RIV/60077344:_____/15:00444024 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/15:43888761
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1532045615000265" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1532045615000265</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbpc.2015.03.006" target="_blank" >10.1016/j.cbpc.2015.03.006</a>
Alternative languages
Result language
angličtina
Original language name
Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila ? A role for dFoxO?
Original language description
Signaling pathways of insect adipokinetic hormones (AKHs) in anti-oxidative response are unclear. Exposure to hydrogen peroxide (HP) revealed that AKH-RNAi flies showed significantly higher mortality than AKH-oex or control lines. AKH-RNAi flies had significantly less dFoxO transcript and translated protein compared to control and AKH-oex flies in un-challenged condition as well as when challenged with HP. Sestrin ? a major antioxidant defense protein and one of the targets of dFoxO ? was also significantly down-regulated in AKH-RNAi flies (both unchallenged and challenged with HP) compared to control flies and flies with over-expressed AKH. These findings imply that dFoxO may act downstream of AKH as a transcription factor to mediate response to OS inD. melanogaster.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Comparative Biochemistry and Physiology Part C
ISSN
1532-0456
e-ISSN
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Volume of the periodical
171
Issue of the periodical within the volume
May 01
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
8-14
UT code for WoS article
000354343400002
EID of the result in the Scopus database
2-s2.0-84925783892