Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00447667" target="_blank" >RIV/60077344:_____/15:00447667 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pbio.1002135" target="_blank" >http://dx.doi.org/10.1371/journal.pbio.1002135</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pbio.1002135" target="_blank" >10.1371/journal.pbio.1002135</a>

Result language

angličtina

Original language name

Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response

Original language description

Immune defense is energetically costly, and thus an effective response requires metabolic adaptation of the organism to reallocate energy from storage, growth, and development towards the immune system. We employ the natural infection of Drosophila witha parasitoid wasp to study energy regulation during immune response. To combat the invasion, the host must produce specialized immune cells (lamellocytes) that destroy the parasitoid egg. We show that a significant portion of nutrients are allocated to differentiating lamellocytes when they would otherwise be used for development. This systemic metabolic switch is mediated by extracellular adenosine released from immune cells. The switch is crucial for an effective immune response. Preventing adenosinetransport from immune cells or blocking adenosine receptor precludes the metabolic switch and the deceleration of development, dramatically reducing host resistance. Adenosine thus serves as a signal that the "selfish" immune cells send d

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLOS BIOLOGY

ISSN

1545-7885

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

23

Pages from-to

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UT code for WoS article

000354824500028

EID of the result in the Scopus database

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