Nucleoside Inhibitors of Tick-Borne Encephalitis Virus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00448138" target="_blank" >RIV/60077344:_____/15:00448138 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00448138 RIV/00027162:_____/15:#0001315 RIV/60076658:12310/15:43888823
Result on the web
<a href="http://dx.doi.org/10.1128/AAC.00807-15" target="_blank" >http://dx.doi.org/10.1128/AAC.00807-15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/AAC.00807-15" target="_blank" >10.1128/AAC.00807-15</a>
Alternative languages
Result language
angličtina
Original language name
Nucleoside Inhibitors of Tick-Borne Encephalitis Virus
Original language description
Tick-borne encephalitis virus (TBEV) is a leading cause of human neuroinfections in Europe and Northeast Asia. There are no antiviral therapies for treating TBEV infection. A series of nucleoside analogues was tested for the ability to inhibit the replication of TBEV in porcine kidney cells and human neuroblastoma cells. The interactions of three nucleoside analogues with viral polymerase were simulated using advanced computational methods. The nucleoside analogues 7-deaza-2'-C-methyladenosine (7-deaza-2'-CMA), 2'-C-methyladenosine (2'-CMA), and 2'-C-methylcytidine (2'-CMC) inhibited TBEV replication. These compounds showed dose-dependent inhibition of TBEV-induced cytopathic effects, TBEV replication (50% effective concentrations [EC50]of 5.1 0.4 muMfor 7-deaza-2'-CMA, 7.1 1.2 muM for 2'-CMA, and 14.2 1.9 muM for 2'-CMC) and viral antigen production. Notably, 2'-CMC was relatively cytotoxic to porcine kidney cells (50% cytotoxic concentration [CC50] of 50 muM). The anti-TBEV effect o
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
5483-5493
UT code for WoS article
000364343900049
EID of the result in the Scopus database
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