Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00449679" target="_blank" >RIV/60077344:_____/15:00449679 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00726-014-1894-9" target="_blank" >http://dx.doi.org/10.1007/s00726-014-1894-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00726-014-1894-9" target="_blank" >10.1007/s00726-014-1894-9</a>

Result language

angličtina

Original language name

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Original language description

Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not known. The three BCAAs: leucine, isoleucine and valine are known to mediate activation of several important hepatic metabolic signaling pathways ranging from insulin signaling to glucose regulation. The purpose of this study is to profile changes in hepatic BCAA metabolite levels with transcriptomic changes in the progression of human NAFLD to discover novel mechanisms of disease progression. Metabolomic and transcriptomic data sets representing the spectrum of human NAFLD (normal, steatosis, NASH fatty, and NASH not fatty livers) were utilized for this study.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Amino Acids

ISSN

0939-4451

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

13

Pages from-to

603-615

UT code for WoS article

000349390700015

EID of the result in the Scopus database

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