Regulation of the Immune Response to alpha-Gal and Vector-borne Diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00450316" target="_blank" >RIV/60077344:_____/15:00450316 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pt.2015.06.016" target="_blank" >http://dx.doi.org/10.1016/j.pt.2015.06.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pt.2015.06.016" target="_blank" >10.1016/j.pt.2015.06.016</a>

Result language

angličtina

Original language name

Regulation of the Immune Response to alpha-Gal and Vector-borne Diseases

Original language description

Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gal alpha 1-3Gal beta 1-(3)4GIcNAc-R (alpha-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-alpha-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight theinterplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of alpha-gal. Establishing the source of alpha-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

—

Project

<a href="/en/project/EE2.3.30.0032" target="_blank" >EE2.3.30.0032: Promotion of post-doctoral positions in the Biology Centre of the Czech Academy of Sciences aimed to build the global competitiveness of the research teams in the Czech Republic</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Trends in Parasitology

ISSN

1471-4922

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

470-476

UT code for WoS article

000363077200005

EID of the result in the Scopus database

—