The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451070" target="_blank" >RIV/60077344:_____/15:00451070 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/15:43889025
Result on the web
<a href="http://www.nature.com/articles/srep15034" target="_blank" >http://www.nature.com/articles/srep15034</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/srep15034" target="_blank" >10.1038/srep15034</a>

Result language
angličtina
Original language name
The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent
Original language description
During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segregated from inner-cell mass (ICM), followed by ICM refinement into either the PrE or EPI. As ICM founders can be produced following the fourth or fifth cleavage divisions, their potential to equally contribute to EPI and PrE is contested. Thus, modelling the early sequestration of ICM founders from TE-differentiation after the fourth cleavage division, we examined ICM lineage contribution of varying sized cell clones unable to initiate TE-differentiation. Such TE-inhibited ICM cells do not equally contribute to EPI and PrE and are significantly biased to form EPI. This bias is not caused by enhanced expression of the EPI marker Nanog, nor correlated with reduced apical polari
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GA13-03295S" target="_blank" >GA13-03295S: Functional characterisation of identified novel candidate cell-fate influencing genes during pre-implantation mouse development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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