Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451293" target="_blank" >RIV/60077344:_____/15:00451293 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s13071-015-1079-8" target="_blank" >http://dx.doi.org/10.1186/s13071-015-1079-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13071-015-1079-8" target="_blank" >10.1186/s13071-015-1079-8</a>
Alternative languages
Result language
angličtina
Original language name
Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection
Original language description
RNA-seq data showed that 2588 genes were differentially expressed in mosquitoes salivary glands in response to P. berghei infection, being 1578 upregulated and 1010 downregulated. Metabolism, Immunity, Replication/Transcription/Translation, Proteolysis and Transport were the mosquito gene functional classes more affected by parasite infection. Endopeptidase coding genes were the most abundant within the differentially expressed genes in infected salivary glands (P < 0.001). Based on its putative function and expression level, the transmembrane glucose transporter gene, AGAP007752, was selected for functional analysis by RNA interference. The results demonstrated that the number of sporozoites was 44.3 % lower in mosquitoes fed on infected mice after AGAPP007752 gene knockdown when compared to control (P < 0.01).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasites Vectors
ISSN
1756-3305
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
SEP 23 2015
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
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UT code for WoS article
000361802900001
EID of the result in the Scopus database
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