Infection dynamics and immune response in a newly described Drosophila-trypanosomatid association/n

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00453442" target="_blank" >RIV/60077344:_____/15:00453442 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >http://dx.doi.org/10.1128/mBio.01356-15</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1128/mBio.01356-15" target="_blank" >10.1128/mBio.01356-15</a>

Result language

angličtina

Original language name

Infection dynamics and immune response in a newly described Drosophila-trypanosomatid association/n

Original language description

Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus, no trypanosomatid parasites naturally infecting Drosophila have been characterized. Here, we establish a new model of trypanosomatid infection in Drosophila-Jaenimonas drosophilae, gen. et sp. nov. As far as we are aware, this is the first Drosophila-parasitic trypanosomatid to be cultured and characterized. Through experimental infections, we find that Drosophila falleni, the natural host, is highly susceptible to infection, leading to a substantial decrease in host fecundity. J. drosophilae has abroad host range, readily infecting a number of Drosophila species, including D. melanogaster, with oral infection of D. melanogaster larvae resulting in the induction of numerous immune genes. When injected into adult hemolymph, J. droso

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA14-23986S" target="_blank" >GA14-23986S: Emergence of pathogenicity for vertebrates: insight from ancestral bodonids and insect trypanosomatids</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

mBio

ISSN

2150-7511

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000364523100041

EID of the result in the Scopus database

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