Strategies for new and improved vaccines against ticks and tick-borne diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468733" target="_blank" >RIV/60077344:_____/16:00468733 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/pim.12339" target="_blank" >http://dx.doi.org/10.1111/pim.12339</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pim.12339" target="_blank" >10.1111/pim.12339</a>

Result language

angličtina

Original language name

Strategies for new and improved vaccines against ticks and tick-borne diseases

Original language description

Ticks infest a variety of animal species and transmit pathogens causing disease in both humans and animals worldwide. Tick-host-pathogen interactions have evolved through dynamic processes that accommodated the genetic traits of the hosts, pathogens transmitted and the vector tick species that mediate their development and survival. New approaches for tick control are dependent on defining molecular interactions between hosts, ticks and pathogens to allow for discovery of key molecules that could be tested in vaccines or new generation therapeutics for intervention of tick-pathogen cycles. Currently, tick vaccines constitute an effective and environmentally sound approach for the control of ticks and the transmission of the associated tick-borne diseases. New candidate protective antigens will most likely be identified by focusing on proteins with relevant biological function in the feeding, reproduction, development, immune response, subversion of host immunity of the tick vector and/or molecules vital for pathogen infection and transmission. This review addresses different approaches and strategies used for the discovery of protective antigens, including focusing on relevant tick biological functions and proteins, reverse genetics, vaccinomics and tick protein evolution and interactomics. New and improved tick vaccines will most likely contain multiple antigens to control tick infestations and pathogen infection and transmission.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA13-11043S" target="_blank" >GA13-11043S: The role of hemoglobin in tick metabolism and transmission of tick-borne pathogens</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasite immunology

ISSN

0141-9838

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

754-769

UT code for WoS article

000390567900006

EID of the result in the Scopus database

2-s2.0-84977506348