Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00483922" target="_blank" >RIV/60077344:_____/17:00483922 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.18632/oncotarget.22428" target="_blank" >http://dx.doi.org/10.18632/oncotarget.22428</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18632/oncotarget.22428" target="_blank" >10.18632/oncotarget.22428</a>

Result language

angličtina

Original language name

Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients

Original language description

Hepatitis B virus (HBV) is one of the most widespread human pathogens causing chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). This study investigated the clinical impact of single and combinational mutations in HBx gene on the pathogenesis of HCC during progressive stages of liver disease. The patients were categorized into inactive HBV carriers, active carriers, cirrhosis and HCC groups based on disease severity. Male sex, age > 50 years, and high serum alanine aminotransferase level were associated with risk of progressive liver disease. I127T, V131I, and F132Y/ I/R mutations showed a significant increasing trend associated with the disease progression to HCC. H94Y and K130M mutations were also significantly associated with severe liver disease. One double mutation (K130M+V131I) and two triple mutations (I127T+K130M+V131L and K130M+V131I+F132Y) were observed, with significant rising prevalence through progressive clinical phases of liver disease to HCC. Several single and combinational mutations in HBx correlating with severity and progressive clinical phases of HBV infection were identified. The mutational combinations may have a synergistic effect in accelerating the progression to HCC. These specific patterns of HBx mutations can be useful in predicting the clinical outcome of HBV-infected patients and may serve as early markers of high risk of developing HCC.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

OncoTarget

ISSN

1949-2553

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

62

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

105115-105125

UT code for WoS article

000419563600033

EID of the result in the Scopus database

2-s2.0-85036538804