Virology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00485360" target="_blank" >RIV/60077344:_____/17:00485360 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/18:N0000251

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Virology

Original language description

TBEV is the most medically important member of the tick-borne serocomplex group within the genus Flavivirus, family Flaviviridae.nThree antigenic subtypes of TBEV correspond to the 3 recognized genotypes: Western, also known as European, Far Eastern, and Siberian. An additional 2 genotypes have been identified in the Irkutsk region of Russia.nTBEV virions are small enveloped spherical particles about 50 nm in diameter.nThe TBEV genome consists of a single-stranded positive sense RNA molecule.nThe genome encodes one open reading frame (ORF), which is flanked by untranslated (non-coding) regions (UTRs).nThe 5′-UTR end has a methylated nucleotide cap for canonical cellular translation. The 3′-UTR is not polyadenylated and is characterized by extensive length and sequence heterogeneity.nThe ORF encodes one large polyprotein, which is co- and post-translationally cleaved into 3 structural proteins (C, prM, and E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).nTBEV replicates in the cytoplasm of the host cell in close association with virus-induced intracellular membrane structures. Virus assembly occurs at the endoplasmic reticulum. The immature virions are transported to the Golgi complex, and mature virions pass through the host secretory pathway and are finally released from the host cell by fusion of the transport vesicle membrane with the plasma membrane.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

10607 - Virology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Tick-Borne Encephalitis (TBE)

ISBN

978-981-11-1903-3

Number of pages of the result

15

Pages from-to

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Number of pages of the book

100

Publisher name

Global Health Press Pte Ltd

Place of publication

Singapore

UT code for WoS chapter

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