Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00502020" target="_blank" >RIV/60077344:_____/17:00502020 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-319-73377-7_15" target="_blank" >http://dx.doi.org/10.1007/978-3-319-73377-7_15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-73377-7_15" target="_blank" >10.1007/978-3-319-73377-7_15</a>
Alternative languages
Result language
angličtina
Original language name
Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model
Original language description
Anaplasma phogocytophihun is an emerging zoonotic pathogen that is transmitted by Ixodes ticks and causes human granulocytic anaplasmosis. Several recent studies have shown that tick infection by A. phagocytophilum induces complex changes mediated by different, mechanisms such as remodeling of cytoskeleton, inhibition of cell apoptosis, modification of metabolism and cell epigenetics, manipulation of the immune response and stress response. In particular, heat shock proteins (lisp), a group of highly conserved proteins, play an important role in tick pathogen interactions. Not only tick ftsp mediate the response to A. phagocytophibun infection, but also bacterial lisp bind tick and vertebrate host cells. Herein, we reviewed the literature and provided new insides on the role of bacterial and tick lisp in tick-pathogen interactions. We combined the analysis of published data on genomics, transcriptomics and proteomics of the response of Ixodes scapularis ticks to A. phagocytophilum infection. In addition, functional. studies were conducted to test some of the hypotheses on the role of tick Hsp in response to A. phagocytophilum infection. These results provide a more comprehensive view of the major Hsp involved in the response to pathogen infection in ticks.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Heat Shock Proteins in Veterinary Medicine and Sciences
ISBN
978-3-319-73376-0
Number of pages of the result
24
Pages from-to
"Roč. 12 /2017/"
Number of pages of the book
398
Publisher name
Springer International Publishing
Place of publication
Cham
UT code for WoS chapter
000448887200016