Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00507407" target="_blank" >RIV/60077344:_____/17:00507407 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10366579

Result on the web

<a href="https://www.nature.com/articles/s41559-017-0092" target="_blank" >https://www.nature.com/articles/s41559-017-0092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41559-017-0092" target="_blank" >10.1038/s41559-017-0092</a>

Result language

angličtina

Original language name

Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes

Original language description

Many anaerobic microbial parasites possess highly modified mitochondria known as mitochondrion-related organelles (MROs). The best-studied of these are the hydrogenosomes of Trichomonas vaginalis and Spironucleus salmonicida, which produce ATP anaerobically through substrate-level phosphorylation with concomitant hydrogen production, and the mitosomes of Giardia intestinalis, which are functionally reduced and lack any role in ATP production. Howewer, to understand the metabolic specializations that these MROs underwent in adaptation to parasitism, data from their free-living relatives are needed. Here, we present a large-scale comparative transcriptomic study of MROs across a major eukaryotic group, Metamonada, examining lineage-specific gain and loss of metabolic functions in the MROs of Trichomonas, Giardia, Spironucleus and their free-living relatives. Our analyses uncover a complex history of ATP production machinery in diplomonads such as Giardia, and their closest relative, Dysnectes, and a correlation between the glycine cleavage machinery and lifestyles. Our data further suggest the existence of a previously undescribed biochemical class of MRO that generates hydrogen but is incapable of ATP synthesis.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10618 - Ecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Ecology & Evolution

ISSN

2397-334X

e-ISSN

—

Volume of the periodical

1

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

0092

UT code for WoS article

000417171500014

EID of the result in the Scopus database

2-s2.0-85029914924