Molecular Evolution and Phylogeny of Leishmania
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F18%3A00502013" target="_blank" >RIV/60077344:_____/18:00502013 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-319-74186-4_2" target="_blank" >http://dx.doi.org/10.1007/978-3-319-74186-4_2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-74186-4_2" target="_blank" >10.1007/978-3-319-74186-4_2</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Evolution and Phylogeny of Leishmania
Original language description
The genus Leishmania was first described in 1903 for the parasite Leishmania donovani, but many additional species have been described since then. Although recent hierarchical taxonomic schemes have increasingly used molecular or biochemical characters to assign Leishmania organisms into different species, they are still heirs of the first classifications based primarily on geographical distribution, vector species, and disease presentations. The current classification system, based on multilocus enzyme electrophoresis, proposes up to 53 species, although molecular phylogenies of Leishmania suggest that the number of species may be too large. Very recently this classification system has been revised based on multiple gene phylogenies. For many decades, there has been a controversial discussion on whether the genus Leishmania appeared first in the Old World or in the New World. Analyses of whole-genome data led to the supercontinent hypothesis, in which the parasites evolved from a monoxenous ancestor on Gondwana and separated into Paraleishmania and all other species around the time when Gondwana split. Many molecular markers have demonstrated substantial intraspecies diversity and the existence of geographically and genetically isolated populations in all Leishmania species tested so far. In particular the idea that Leishmania evolve predominantly clonally with only rare sexual recombination has repeatedly been questioned by the detection of hybrids, mosaic genotypes, and gene flow between populations and strong inbreeding and, finally, the detection of genetic recombination under laboratory conditions. This chapter reviews the recent (mostly) molecular data that provide new insights into the evolution, taxonomy, phylogenetic, and population genetic relationships of Leishmania but also the questions raised by this knowledge. It also discusses the power of modern approaches, such as multilocus sequence analysis, multilocus microsatellite typing, and comparative genomics for studying the inter- and intraspecies variation of Leishmania parasites.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments
ISBN
978-3-319-74185-7
Number of pages of the result
39
Pages from-to
19-57
Number of pages of the book
376
Publisher name
Springer International Publishing
Place of publication
Cham
UT code for WoS chapter
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