Molecular Targets to Impair Blood Meal Processing in Ticks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F18%3A00503008" target="_blank" >RIV/60077344:_____/18:00503008 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/9783527802883.ch7" target="_blank" >http://dx.doi.org/10.1002/9783527802883.ch7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/9783527802883.ch7" target="_blank" >10.1002/9783527802883.ch7</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Targets to Impair Blood Meal Processing in Ticks
Original language description
Feeding and digestion of host blood are key physiological processes providing essential nutrients for the development and fecundity of ticks. Ingested host blood, which exceeds the weight of unfed females by more than one hundred times, is concentrated and stored in the tick gut lumen, gradually being taken up by digestive cells, and intracellularly digested by a multi‐enzyme network of acidic aspartic and cysteine endo‐ and exo‐peptidases. Digestion of hemoglobin, the major protein component of blood, results in the release of a vast excess of potentially toxic heme. In most eukaryotic cells, heme and iron homeostasis is based on a balanced flux between heme biosynthesis and heme degradation, mediated by heme oxygenase. In contrast, ticks are not capable of synthesizing or degrading heme. Therefore, ticks have evolved specific molecular mechanisms of heme and iron acquisition, detoxification, intracellular trafficking, and inter‐tissue transport. This chapter reviews current knowledge on the molecular mechanisms of these processes and discusses their potential as targets for antitick interventions.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Ectoparasites: Drug Discovery Against Moving Targets
ISBN
9783527341689
Number of pages of the result
26
Pages from-to
139-165
Number of pages of the book
360
Publisher name
Wiley‐VCH Verlag GmbH & Co. KGaA.
Place of publication
Wenheim
UT code for WoS chapter
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