Yeast glucan particles enable intracellular protein delivery in Drosophila without compromising the immune system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00510039" target="_blank" >RIV/60077344:_____/19:00510039 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/19:43899740
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/BM/C9BM00539K#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/BM/C9BM00539K#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9bm00539k" target="_blank" >10.1039/c9bm00539k</a>
Alternative languages
Result language
angličtina
Original language name
Yeast glucan particles enable intracellular protein delivery in Drosophila without compromising the immune system
Original language description
Glucan particles derived from yeast have been recently proposed as potential drug delivery carriers. Here, we demonstrate the potential of glucan particles for protein delivery in vivo, using the insect Drosophila melanogaster as a model organism. By employing genetic tools, we demonstrate the capacity of yeast glucan particles to spread efficiently through the Drosophila body, to enter macrophages and to deliver an active transcription factor protein successfully. Moreover, the glucan particles were nontoxic and induced only minimal immune response. The injection of glucan particles did not impair the ability of Drosophila to fight and survive infection by pathogenic bacteria. From this study, Drosophila emerges as an excellent model to test and develop drug delivery systems based on glucan particles, specifically aimed to regulate macrophages.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomaterials Science
ISSN
2047-4830
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
4708-4719
UT code for WoS article
000498818900021
EID of the result in the Scopus database
2-s2.0-85073665251