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The kinetochore and the origin of eukaryotic chromosome segregation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519521" target="_blank" >RIV/60077344:_____/19:00519521 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.pnas.org/doi/full/10.1073/pnas.1908067116" target="_blank" >https://www.pnas.org/doi/full/10.1073/pnas.1908067116</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The kinetochore and the origin of eukaryotic chromosome segregation

  • Original language description

    All organisms must faithfully segregate their DNA during cell division to safeguard complete inheritance of the genome. In eukaryotes, mechanisms of cell and nuclear division are highly variable, and while these usually involve the use of a mitotic microtubule-based spindle and a kinetochore (KT) that physically links the chromatin and spindle, beyond this, the arrangement and manner in which mitosis is completed can adopt one of a vast number of disparate pathways (1, 2). Each of these pathways requires the participation of multiple cellular functions, including the nucleoskeleton, centromeres (chromatin-marked KT assembly sites), the nuclear envelope, and the nuclear pore complex (NPC), to achieve the ultimate goal of partitioning a complete genome to both daughter cells. Because the eukaryotic genome is contained on multiple DNA elements and is frequently diploid makes this task even more challenging. In PNAS, Tromer et al. (3) revisit the origin of a key component, the KT, using highly sensitive sequence and architectural search methods to provide a possible evolutionary history.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů