Antiviral activity of uridine derivatives of 2-deoxy sugars against tick-borne encephalitis virus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519824" target="_blank" >RIV/60077344:_____/19:00519824 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/19:N0000042

Result on the web

<a href="https://www.mdpi.com/1420-3049/24/6/1129" target="_blank" >https://www.mdpi.com/1420-3049/24/6/1129</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules24061129" target="_blank" >10.3390/molecules24061129</a>

Result language

angličtina

Original language name

Antiviral activity of uridine derivatives of 2-deoxy sugars against tick-borne encephalitis virus

Original language description

Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system. Although effective vaccines are available on the market, they are recommended only in endemic areas. Despite many attempts, there are still no specific antiviral therapies for TBEV treatment. Previously, we synthesized a series of uridine derivatives of 2-deoxy sugars and proved that some compounds show antiviral activity against viruses from the Flaviviridae and Orthomyxoviridae families targeting the late steps of the N-glycosylation process, affecting the maturation of viral proteins. In this study, we evaluated a series of uridine derivatives of 2-deoxy sugars for their antiviral properties against two strains of the tick-borne encephalitis virus, the highly virulent TBEV strain Hypr and the less virulent strain Neudoerfl. Four compounds (2, 4, 10, and 11) showed significant anti-TBEV activity with IC50 values ranging from 1.4 to 10.2 µM and low cytotoxicity. The obtained results indicate that glycosylation inhibitors, which may interact with glycosylated membrane TBEV E and prM proteins, might be promising candidates for future antiviral therapies against TBEV.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

1129

UT code for WoS article

000465503800105

EID of the result in the Scopus database

2-s2.0-85063590684