NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00520226" target="_blank" >RIV/60077344:_____/19:00520226 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12220/19:43900296
Result on the web
<a href="https://gutpathogens.biomedcentral.com/track/pdf/10.1186/s13099-019-0293-x" target="_blank" >https://gutpathogens.biomedcentral.com/track/pdf/10.1186/s13099-019-0293-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13099-019-0293-x" target="_blank" >10.1186/s13099-019-0293-x</a>

Result language
angličtina
Original language name
NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome
Original language description
BackgroundCryptosporidium is an important gut microbe whose contributions towards infant and immunocompromise patient mortality rates are steadily increasing. Over the last decade, we have seen the development of various tools and methods for studying Cryptosporidium infection and its interactions with their hosts. One area that is sorely overlooked is the effect infection has on host metabolic processes.ResultsUsing a H-1 nuclear magnetic resonance approach to metabolomics, we have explored the nature of the mouse gut metabolome as well as providing the first insight into the metabolome of an infected cell line. Statistical analysis and predictive modelling demonstrated new understandings of the effects of a Cryptosporidium infection, while verifying the presence of known metabolic changes. Of note is the potential contribution of host derived taurine to the diarrhoeal aspects of the disease previously attributed to a solely parasite-based alteration of the gut environment, in addition to other metabolites involved with host cell catabolism.ConclusionThis approach will spearhead our understanding of the Cryptosporidium-host metabolic exchange and provide novel targets for tackling this deadly parasite.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
40301 - Veterinary science

Project
<a href="/en/project/GA15-01090S" target="_blank" >GA15-01090S: Revealing Cryptosporidium diversity: Linking genetic variation to parasite biology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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