Tracking of Borrelia afzelii Transmission from Infected Ixodes ricinus Nymphs to Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00520425" target="_blank" >RIV/60077344:_____/19:00520425 - isvavai.cz</a>
Result on the web
<a href="https://iai.asm.org/content/iai/87/6/e00896-18.full.pdf" target="_blank" >https://iai.asm.org/content/iai/87/6/e00896-18.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/IAI.00896-18" target="_blank" >10.1128/IAI.00896-18</a>
Alternative languages
Result language
angličtina
Original language name
Tracking of Borrelia afzelii Transmission from Infected Ixodes ricinus Nymphs to Mice
Original language description
Quantitative and microscopic tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs has shown a transmission cycle different from that of Borrelia burgdorferi and Ixodes scapularis. Borrelia afzelii organisms are abundant in the guts of unfed I. ricinus nymphs, and their numbers continuously decrease during feeding. Borrelia afzelii spirochetes are present in murine skin within 1 day of tick attachment. In contrast, spirochetes were not detectable in salivary glands at any stage of tick feeding. Further experiments demonstrated that tick saliva is not essential for B. afzelii infectivity, the most important requirement for successful host colonization being a change in expression of outer surface proteins that occurs in the tick gut during feeding. Spirochetes in vertebrate mode are then able to survive within the host even in the absence of tick saliva. Taken together, our data suggest that the tick gut is the decisive organ that determines the competence of I. ricinus to vector B. afzelii. We discuss possible transmission mechanisms of B. afzelii spirochetes that should be further tested in order to design effective preventive and therapeutic strategies against Lyme disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INFECTION AND IMMUNITY
ISSN
1098-5522
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
e00896-18
UT code for WoS article
000468521100009
EID of the result in the Scopus database
2-s2.0-85064456471