The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00510737" target="_blank" >RIV/60077344:_____/20:00510737 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S014765131931214X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S014765131931214X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ecoenv.2019.109883" target="_blank" >10.1016/j.ecoenv.2019.109883</a>
Alternative languages
Result language
angličtina
Original language name
The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study
Original language description
The effects of pure glyphosate [N-(phosphonomethyl)-glycine], RCP and a non-ionic surfactant – polyethoxylated tallowamine (POEA) were studied in the fruit fly Drosophila melanogaster in order to develop an understanding of the role of adjuvants in a popular glyphosate-based herbicide – Roundup® Concentrate Plus (RCP). Acute exposure to sub-lethal concentrations of RCP and POEA reduced lifespan of female flies compared to untreated controls or glyphosate. Negative geotaxis responses in female flies were reduced following acute exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not significantly affect this response compared to untreated flies. Acute exposure to sub-lethal concentrations of RCP and POEA elevated protein carbonyl levels while markedly inhibiting carbonyl reductase activity whereas glyphosate treatment did not significantly affect protein carbonyl levels or carbonyl reductase activity. Fecundity was reduced following exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not affect fecundity. In vitro treatment of ovarian stem sheath cells with sub-lethal concentrations of RCP and POEA revealed decreased cell viability and enhanced caspase activity indicative of pro-apoptotic processes compared to untreated controls. Glyphosate however was non-toxic at the concentration used. The results suggest that RCP and the surfactant POEA are more toxic than pure glyphosate and inhibit fecundity in Drosophila by inhibiting cell viability through enhanced apoptosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)
Result continuities
Project
<a href="/en/project/EF18_070%2F0008772" target="_blank" >EF18_070/0008772: An expanded view of energy homeostasis: neural integration of insulin and adipokinetic hormone signalling</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ecotoxicology and Enviromental Safety
ISSN
0147-6513
e-ISSN
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Volume of the periodical
188
Issue of the periodical within the volume
JAN 30
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
109883
UT code for WoS article
000503913900005
EID of the result in the Scopus database
2-s2.0-85074361084