Inhibition of pro-inflammatory cytokines by metabolites of streptomycetes-a potential alternative to current anti-inflammatory drugs?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00531233" target="_blank" >RIV/60077344:_____/20:00531233 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/20:43901261 RIV/00216208:11110/20:10412619

Result on the web

<a href="https://www.mdpi.com/2076-2607/8/5/621" target="_blank" >https://www.mdpi.com/2076-2607/8/5/621</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/microorganisms8050621" target="_blank" >10.3390/microorganisms8050621</a>

Result language

angličtina

Original language name

Inhibition of pro-inflammatory cytokines by metabolites of streptomycetes-a potential alternative to current anti-inflammatory drugs?

Original language description

Current treatment of chronic diseases includes, among others, application of cytokines, monoclonal antibodies, cellular therapies, and immunostimulants. As all the underlying mechanisms of a particular diseases are not always fully clarified, treatment can be inefficient and associated with various, sometimes serious, side effects. Small secondary metabolites produced by various microbes represent an attractive alternative as future anti-inflammatory drug leads. Compared to current drugs, they are cheaper, can often be administered orally, but still can keep a high target-specificity. Some compounds produced by actinomycetes or fungi have already been used as immunomodulators—tacrolimus, sirolimus, and cyclosporine. This work documents strong anti-inflammatory features of another secondary metabolite of streptomycetes—manumycin-type polyketides. We compared the effect of four related compounds: manumycin A, manumycin B, asukamycin, and colabomycin E on activation and survival of human monocyte/macrophage cell line THP-1. The anti-cancer effect of manumycine A has been demonstrated, the immunomodulatory capacities of manumycin A are obvious when using micromolar concentrations. The application of all four compounds in 0.25–5 µM concentrations leads to efficient, concentration-dependent inhibition of IL-1β and TNF expression in THP-1 upon LPS stimulation, while the three latter compounds show a significantly lower pro-apoptotic effect than manumycin A. We have demonstrated the anti-inflammatory capacity of selected manumycin-type polyketides.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10609 - Biochemical research methods

Project

<a href="/en/project/NV17-30091A" target="_blank" >NV17-30091A: Unique biosynthetic enzymes as the key to novel bioactive compounds</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microorganisms

ISSN

2076-2607

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

621

UT code for WoS article

000540222300002

EID of the result in the Scopus database

2-s2.0-85083968106