Mapping the Gene Expression Spectrum of Mediator Subunits in Response to Viroid Infection in Plants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00532467" target="_blank" >RIV/60077344:_____/20:00532467 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/21/7/2498/htm" target="_blank" >https://www.mdpi.com/1422-0067/21/7/2498/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21072498" target="_blank" >10.3390/ijms21072498</a>
Alternative languages
Result language
angličtina
Original language name
Mapping the Gene Expression Spectrum of Mediator Subunits in Response to Viroid Infection in Plants
Original language description
The mediator (MED) represents a large, conserved, multi-subunit protein complex that regulates gene expression through interactions with RNA polymerase II and enhancer-bound transcription factors. Expanding research accomplishments suggest the predominant role of plant MED subunits in the regulation of various physiological and developmental processes, including the biotic stress response against bacterial and fungal pathogens. However, the involvement of MED subunits in virus/viroid pathogenesis remains elusive. In this study, we investigated for the first time the gene expression modulation of selected MED subunits in response to five viroid species (Apple fruit crinkle viroid (AFCVd), Citrus bark cracking viroid (CBCVd), Hop latent viroid (HLVd), Hop stunt viroid (HSVd), and Potato spindle tuber viroid (PSTVd)) in two model plant species (Nicotiana tabacum and N. benthamiana) and a commercially important hop (Humulus lupulus) cultivar. Our results showed a differential expression pattern of MED subunits in response to a viroid infection. The individual plant MED subunits displayed a differential and tailored expression pattern in response to different viroid species, suggesting that the MED expression is viroid- and plant species-dependent. The explicit evidence obtained from our results warrants further investigation into the association of the MED subunit with symptom development. Together, we provide a comprehensive portrait of MED subunit expression in response to viroid infection and a plausible involvement of MED subunits in fine-tuning transcriptional reprogramming in response to viroid infection, suggesting them as a potential candidate for rewiring the defense response network in plants against pathogens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/EF16_027%2F0008357" target="_blank" >EF16_027/0008357: International Mobilities of Researchers of the Biology Centre</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
2498
UT code for WoS article
000535574200240
EID of the result in the Scopus database
2-s2.0-85083022621