Interspecies variation in hominid gut microbiota controls host gene regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00554381" target="_blank" >RIV/60077344:_____/21:00554381 - isvavai.cz</a>
Alternative codes found
RIV/68081766:_____/21:00549092
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2211124721015436" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2211124721015436</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2021.110057" target="_blank" >10.1016/j.celrep.2021.110057</a>
Alternative languages
Result language
angličtina
Original language name
Interspecies variation in hominid gut microbiota controls host gene regulation
Original language description
The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn's disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/LH15175" target="_blank" >LH15175: Functional interaction between host gene regulation and the microbiome in the primate gut</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
2211-1247
Volume of the periodical
37
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
110057
UT code for WoS article
000722835600002
EID of the result in the Scopus database
2-s2.0-85119507935