Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00555307" target="_blank" >RIV/60077344:_____/21:00555307 - isvavai.cz</a>
Result on the web
<a href="https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095091093095091424170" target="_blank" >https://2021.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170095091093095091424170</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Quantitative analysis of the dormant Mycobacterium tuberculosis proteome and prognostic value of some protein antigens for tuberculosis serodiagnosis
Original language description
Formation of dormant Mycobacterium tuberculosis (Mtb) cells is responsible for the phenomenon of latent tuberculosis. Serodiagnosis is an effective method for early detection of pathogen for many infection diseases. However, this method demonstrates low effectiveness for TB detection that could be due to incorrect antigens selected. We suggest to study the expression of protein antigens in dormant state of Mtb in vitro (5 mo old cells) obtained under gradual medium acidification which may reflect the real situation for the pathogen in case of latent TB. Analysis of the proteomic profile of active and dormant Mtb was carried out by LCMS/MS.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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