Genome analysis of Candida subhashii reveals its hybrid nature and dual mitochondrial genome conformations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00559976" target="_blank" >RIV/60077344:_____/21:00559976 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/dnaresearch/article/28/3/dsab006/6299387?login=true" target="_blank" >https://academic.oup.com/dnaresearch/article/28/3/dsab006/6299387?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/dnares/dsab006" target="_blank" >10.1093/dnares/dsab006</a>
Alternative languages
Result language
angličtina
Original language name
Genome analysis of Candida subhashii reveals its hybrid nature and dual mitochondrial genome conformations
Original language description
Candida subhashii belongs to the CUG-Ser Glade, a group of phylogenetically closely related yeast species that includes some human opportunistic pathogens, such as Candida albicans. Despite being present in the environment, C. subhashii was initially described as the causative agent of a case of peritonitis. Considering the relevance of whole-genome sequencing and analysis for our understanding of genome evolution and pathogenicity, we sequenced, assembled and annotated the genome of C. subhashii type strain. Our results show that C. subhashii presents a highly heterozygous genome and other signatures that point to a hybrid ancestry. The presence of functional pathways for assimilation of hydroxyaromatic compounds goes in line with the affiliation of this yeast with soil microbial communities involved in lignin decomposition. Furthermore, we observed that different clones of this strain may present circular or linear mitochondrial DNA. Re-sequencing and comparison of strains with differential mitochondrial genome topology revealed five candidate genes potentially associated with this conformational change: MSK1, SSZ1, ALG5, MRPL9 and OYE32.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dna Research
ISSN
1340-2838
e-ISSN
1756-1663
Volume of the periodical
28
Issue of the periodical within the volume
3
Country of publishing house
JP - JAPAN
Number of pages
9
Pages from-to
dsab006
UT code for WoS article
000743559800002
EID of the result in the Scopus database
2-s2.0-85112486695