Coatomer in the universe of cellular complexity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00565965" target="_blank" >RIV/60077344:_____/22:00565965 - isvavai.cz</a>
Result on the web
<a href="https://www.molbiolcell.org/doi/full/10.1091/mbc.E19-01-0012" target="_blank" >https://www.molbiolcell.org/doi/full/10.1091/mbc.E19-01-0012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1091/mbc.E19-01-0012" target="_blank" >10.1091/mbc.E19-01-0012</a>

Result language
angličtina
Original language name
Coatomer in the universe of cellular complexity
Original language description
Eukaryotic cells possess considerable internal complexity, differentiating them from prokaryotes. Eukaryogenesis, an evolutionary transitional period culminating in the last eukaryotic common ancestor (LECA), marked the origin of the eukaryotic endomembrane system. LECA is reconstructed as possessing intracellular complexity akin to modern eukaryotes. Construction of endomembrane compartments involved three key gene families: coatomer, BAR-domain proteins, and ESCRT. Each has a distinct evolutionary origin, but of these coatomer and BAR proteins are eukaryote specific, while ESCRT has more ancient origins. We discuss the structural motifs defining these three membrane-coating complexes and suggest that compared with BAR and ESCRT, the coatomer architecture had a unique ability to be readily and considerably modified, unlocking functional diversity and enabling the development of the eukaryotic cell.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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