Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00570206" target="_blank" >RIV/60077344:_____/23:00570206 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0010854523000139?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010854523000139?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2023.215024" target="_blank" >10.1016/j.ccr.2023.215024</a>

Result language

angličtina

Original language name

Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

Original language description

Ferroptosis is a type of iron-mediated cell death merging cell metabolism, redox status, and human dis-ease. Reactive oxygen species (ROS) are formed after exposure to xenobiotics and normal metabolism, depending on their level, ROS can serve as intracellular redox messengers and regulators of cell fate, while excessive ROS amounts cause cellular oxidative changes, suppress protein activity, and trigger cell death. At the intracellular level, several redox mechanisms, such as the pyridine nucleotide redox systems involving thioredoxin and glutathione, are connected with ROS signaling and therefore contribute to cell status and function. Living in polluted conditions with an increased presence of fossil fuels, negatively affects human health and makes humans vulnerable to debilitating problems such as cancer and infec-tious diseases. The present understanding of ferroptosis in toxicity-mediated environmental exposures remains incomplete, and the underlying basis for the chemical stressors that trigger ferroptosis remains unclear. This review summarized the effects of environmental chemical exposure on cellular redox sig-naling, ferroptosis, and cell death providing critical information to stop the impact of ferroptosis on human health. (c) 2023 Elsevier B.V. All rights reserved.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Coordination Chemistry Reviews

ISSN

0010-8545

e-ISSN

1873-3840

Volume of the periodical

480

Issue of the periodical within the volume

JAN

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

215024

UT code for WoS article

000931547800001

EID of the result in the Scopus database

2-s2.0-85147110243