Functional differentiation of Sec13 paralogues in the euglenozoan protists

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00574461" target="_blank" >RIV/60077344:_____/23:00574461 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/23:43906434 RIV/00216224:90242/23:00133778 RIV/61988987:17310/23:A2402LBM RIV/00216208:11310/23:10465402
Result on the web
<a href="https://royalsocietypublishing.org/doi/10.1098/rsob.220364" target="_blank" >https://royalsocietypublishing.org/doi/10.1098/rsob.220364</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rsob.220364" target="_blank" >10.1098/rsob.220364</a>

Result language
angličtina
Original language name
Functional differentiation of Sec13 paralogues in the euglenozoan protists
Original language description
The beta-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore complex (NPC) and the Seh1-associated (SEA)/GATOR nutrient-sensing complex. This suggests that regulatory mechanisms coordinating these cellular activities may operate via Sec13. The NPC, COPII and SEA/GATOR are all ancient features of eukaryotic cells, and in the vast majority of eukaryotes, a single Sec13 gene is present. Here we report that the Euglenozoa, a lineage encompassing the diplonemid, kinetoplastid and euglenid protists, possess two Sec13 paralogues. Furthermore, based on protein interactions and localization studies we show that in diplonemids Sec13 functions are divided between the Sec13a and Sec13b paralogues. Specifically, Sec13a interacts with COPII and the NPC, while Sec13b interacts with Sec16 and components of the SEA/GATOR complex. We infer that euglenozoan Sec13a is responsible for NPC functions and canonical anterograde transport activities while Sec13b acts within nutrient and autophagy-related pathways, indicating a fundamentally distinct organization of coatomer complexes in euglenozoan flagellates.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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